European Journal of Cardiovascular Medicine

Background:

Siddha system of medical has developed a rich and unique treasure of drug knowledge in which use of plants, metals and minerals is very much advocated, which plays an important role in medicinal properties for both preventive and curative. These medicinal values of plants are in some chemically active substance they produce a definite physiological action on the human body. Kanda aviltham is a classic siddha medicine used in the treatment of suram, mukkutranoigal, naavaratchi. Vaanthi, malapantham, malapokku, neerkatti, etc.

Objective:

1. Anti-coagulant activity

2. Safety profile of kandha aviltham on mammalian cell A, Erythrocytes

B, Fibroblasts

Method:

1. Anti-coagulant activity

•Platelet aggregration assay [Human]

•Dose dependent assay/ 3hrs treatment

2. Safety profile

•MTT assay on NIH3T3 fibroblast, dose dependent assay/ 24 hrs treatment

•Hemolytic assay on human erythrocyte, dose dependent assay/ 1hrs treatment

Conclusion: The Anti-coagulant study, Fibroblastic toxicity and hemolytic study for kanda aviltham shows the drug is non- cytotoxic and it contains anti-coagulant and hemolytic activity.This evidence based data provides valuable information is helful to standardization of kandha aviltham.