European Journal of Cardiovascular Medicine

Background: Dengue, is an arthropod-borne viral disease of significant public health importance. In the context of the rising burden of Dengue in South Odisha, this hospital-based cross-sectional study conducted at MKCG Medical College Hospital, Berhampur, aims to evaluate liver function tests in 100 Dengue patients. Recognizing the significance of hepatic involvement in Dengue, the study seeks to contribute valuable insights into the hepatic manifestations of the disease, potentially enhancing diagnostic and management strategies in this region. Methodology: Utilizing a systematic approach, this study employed a cross-sectional design at MKCG Medical College Hospital, Berhampur, enrolling 100 Dengue patients. Standardized liver function tests were conducted, including serum bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase. Data analysis involved descriptive statistics, providing a comprehensive overview of hepatic parameters in Dengue patients within the specified tertiary care setting Results: Among 100 Dengue patients, 40% exhibited less than a 2-fold increase in AST levels, while 28% showed a 2-10-fold rise, and 10% demonstrated more than a 10-fold increase. Overall, 22% maintained normal SGOT values, with 78% displaying elevated levels. Regarding SGPT, 20% had normal values, 35% presented with less than a 2-fold increase, 25% displayed a 2-10-fold rise, and 20% had more than a 10-fold increase from normal levels. Early-stage symptoms like vomiting and abdominal pain correlated with hepatic involvement, with statistically higher AST and ALT levels in patients developing complications such as DHF, DSS, hepatic failure, ARDS, AKI, and encephalopathy Conclusion: In summary, our study reveals a notable prevalence of hepatic involvement in Dengue patients, emphasizing the significance of vigilant monitoring, particularly in cases with early symptoms and those at risk of complications. These findings offer crucial insights for tailored interventions and enhanced patient care within the tertiary care context of South Odisha.