European Journal of Cardiovascular Medicine

Non-alcoholic fatty liver disease (NAFLD) is a prevalent and progressive liver condition with significant health implications. This study aimed to investigate the sonographic evaluation of NAFLD and its correlation with the non-HDL cholesterol to HDL cholesterol ratio, a marker of dyslipidemia. A total of 200 participants with suspected or known NAFLD were included in the study. Sonographic evaluations were performed to assess the severity of NAFLD in terms of increase in liver echogenicity, liver to kidney contrast, blurring of intrahepatic vessel borders and diaphragm. Non-HDL cholesterol to HDL cholesterol ratio was calculated from lipid profile results. The study found a positive correlation between the non-HDL cholesterol to HDL cholesterol ratio and the severity of sonographic features of NAFLD. Participants with a higher ratio exhibited more severe grade of NAFLD. Furthermore, the non-HDL cholesterol to HDL cholesterol ratio was higher in participants who showed NAFLD progression compared to those who did not progress, suggesting its potential as a predictive marker for disease progression. These findings contribute to our understanding of NAFLD and highlight the association between dyslipidemia and disease severity. The non-HDL cholesterol to HDL cholesterol ratio may serve as a non-invasive marker for disease severity and progression, aiding in risk stratification and therapeutic interventions. Further research is needed to validate these results and explore the clinical implications of this association.