European Journal of Cardiovascular Medicine

Background: Osteoarthritis (OA) is characterised by joint damage, hyperplasia, and degeneration of articular cartilage. In Knee Osteoarthritis KOA pathophysiology, the immune and inflammatory systems are stimulated, and monocytes, neutrophils, lymphocytes, and platelets play significant roles. Neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) can indicate the balance of the immune response and have been described as independent and cost-effective predictors of numerous inflammatory and immunological illnesses. The present study aimed to study of Biochemical marker in Knee Osteoarthritis. Method: In the present case-control study, a total of 100 KOA cases and 100 healthy were enrolled as per inclusion-exclusion criteria. Patient data, including age, sex, blood cell counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, red blood cell distribution width, and the Kellgren–Lawrence (KL) score were recorded. Result: The mean age in both cases [56.78±9.61] and the control group [55.37±8.42] were comparable. Male had dominancy in both groups over females however showed a non-significant difference among both groups. Majority of patients were of OA Grade-II (56%). While ROC analysis, all markers showed significant observation (except RBC) with maximum AUC in lymphocytes (0.9871) and neutrophils (0.8310). Amongst the ratio, NLR showed the most significant AUC (0.7815) and correlation (r=0.423) values. All parameters showed a significant correlation with OA grade except Age [p=0.1526], Platelets [p=0.0986], and red blood cell distribution width [p=0.0705]. Conclusion: NLR has a high diagnostic value for KOA, so that it could be a trustworthy marker. However, further multi-centre studies need to increase the reliability of the present observations.