European Journal of Cardiovascular Medicine

Background:  Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It may be due to impaired insulin secretion, resistance to peripheral actions of insulin, or both. According to the International Diabetes Federation (IDF), approximately 415 million adults between the ages of 20 to 79 years had diabetes mellitus in 2015. [1] DM is proving to be a global public health burden as this number is expected to rise to another 200 million by 2040. This is a Prospective, Cross sectional, Randomization, Observational study wa conducted in the Department of Biochemistry and Medicine, Index Medical College. Inclusion Criteria: Controls without family history of type 2 diabetes: Healthy subjects in the age group of 18 - 30 years of either Gender. Exclusion Criteria: Individuals who are using any medicines for any health condition to restrict in performing sub-maximal exercise. TAOS while comparing between control group (without family history of type 2 diabetes) and case group (with family history of type 2 diabetes), in our study found that in mean and standard deviation of TAOS in 18- 21 years in control group (1.45 + 0 .34 mM) and case group (0.71 + 0.46 mM) was statistically not significant difference between both groups (p=0.061), meanwhile TAOS in 22- 25 years in control group (1.37 + 0 .47 mM) and case group (0.45 + 0.14 mM) was statistically significant difference between both groups (p=0.003). MDA in 18-21 years in Case Group showed an increase in Mean 11.05 + 9.26 mM then control group 6.14 + 0.89m M (p<0.0001), MDA in 22-25 years in Case Group showed an increase in Mean 13.05 + 9.34 mM then control group 5.74 + 1.19m M.