European Journal of Cardiovascular Medicine

Introduction: Thyroxine (T4) and triidiothyronine (T3), two related hormones produced by the thyroid gland. Thyrotoxicosis, a condition in which the thyroid gland produces too many thyroid hormones, or hormone shortage, which results from glandular damage (hypothyroidism). Objective: The objective of the study was to examine the effect of thyroid hormone replacement (L thyroxin) on left ventricular diastolic dysfunction in patients with overt hypothyroidism. Materials and Methods: The present study was a case-control study. This Study was conducted from April 2021 to November 2022 at Department of General Medicine at PMCH, Patna. Result: Serum TSH level showed a significant decrease in patients from 56.458m Iu/L (±13.032) to 17.932mIu/L (±11.040) after 3 months of L- thyroxine therapy. Serum T3 & T4 showed a significant rise in patients from 0.838 (±0.035) Nmol/L to 2.069 (±0.036)Nmol/L and 44.678 (±8.673) Nmol/L to 92.358 (±13.011)Nmol/L respectively after 3 months of treatment. Conclusion: In conclusion, diastolic dysfunction of LV is abnormal in patient in hypothyroidism, which can be reversed by L-thyroxine therapy. Doppler echocardiography is reliable, simple, and inexpensive method for assessment of diastolic dysfunction.