European Journal of Cardiovascular Medicine

Background: Diabetes mellitus is a metabolic syndrome associated to a number of vascular and non-vascular problems. Hyperglycemia is the main presenting symptom of the metabolic syndrome. Oxidative stress caused on by hyperglycemia induced vascular damage, generation of proinflammatory cytokines, and growth factors. Chemerin was identified as an adipokine and its role in regulating adipogenesis and adipocyte metabolism was connected to metabolic syndrome. The goal of the current analysis was to assess the levels of serum chemerin in T2DM patients. Methods: The outcomes of 24 published studies that examined at serum chemerin levels in T2DM patients were exposed to meta-analysis. An estimation of the serum chemerin pooled mean was made using a random-effects model. Results: According to our meta-analysis research, the pooled mean of serum chemerin in diabetes mellitus patients was 169.82 ng/ml, which is higher than the healthy control (131.94 ng/ml).Conclusion: The meta-analyses revealed a significant relationship between diabetes mellitus and serum chemerin concentrations. These findings also suggest that routine measurement and evaluation of serum chemerin will contribute in the management of diabetes mellitus