Drug–Drug Interactions among Critically Ill Patients with Chronic Kidney Disease Management

doi:10.5083/ejcm

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Research Article | Volume 13 Issue:1 (, 2023) | Pages 400 - 407

Drug–Drug Interactions among Critically Ill Patients with Chronic Kidney Disease Management

Under a Creative Commons license

Open Access

DOI : 10.5083/ejcm

Published

Feb. 9, 2023

Abstract

Background: Chronic kidney disease (CKD) is a long-term condition characterized by a gradual loss of kidney functions, usually accompanied by other comorbidities including cardiovascular diseases (hypertension, heart failure and stroke) and diabetes mellitus. Epidemiological and clinical observations have shown that polypharmacy may increase the probability of adverse drug reactions (ADRs), possibly through a higher risk of drug-drug interactions (DDIs). Renal impairment may further worsen this scenario by affecting the physiological and biochemical pathways underlying pharmacokinetics and ultimately modifying the pharmacodynamic responses

Keywords

Chronic Kidney Disease

Drug-drug interactions

Hypertension

European Journal of Cardiovascular Medicine

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