European Journal of Cardiovascular Medicine

Object: This study aimed to investigate the status of Malondialdehyde (MDA) concentration and the activity of antioxidative enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in both gastric cancer patients and healthy controls. The role of enzymatic antioxidant activity in cell protection from the damages caused by oxidative stress was also examined. The differences between the lipid peroxidation levels and defense mechanisms of the two groups were analyzed and compared. Materials and Methods: This study was conducted on 50 patients diagnosed with gastric cancer and 50 healthy control subjects of the same age and gender. Spectrophotometric techniques were used to measure the activity of malondialdehyde, glutathione peroxidase, and superoxide dismutase. Results: The results of this study revealed that there was a significant increase in MDA and a highly significant alteration in antioxidants. Conclusion: The diagnosis of human gastric cancer or recurrence could be aided by studying the lipid peroxidation and antioxidant defense mechanisms, in addition to using biopsy, biochemical, and pathological investigations. This combination of methods may be a more effective tool