Nitric Oxide to Treat ARDS by a Mobile NO Generator

doi:10.5083/ejcm

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Research Article | Volume 10 Issue :1 (, 2020) | Pages 11 - 15

Nitric Oxide to Treat ARDS by a Mobile NO Generator

Under a Creative Commons license

Open Access

DOI : 10.5083/ejcm

Published

March 25, 2020

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a major medical emergency requesting acute therapeutic intervention. Here we report that Nitric Oxide (NO) gas attenuates ARDS in mice. Using a novel portable NO generator we found that NO at 20 ppm attenuates endotoxin (LPS) induced neutrophil recruitment lung alveolar epithelial damage reduced inflammatory cytokines, neutrophil. Therefore, the data suggest that the use of a portable NO generator may be considered as an interesting therapeutic possibility for patients with severe ARDS.

Keywords

ARDS

Endotoxin

Nitric oxide

NO portable generator

European Journal of Cardiovascular Medicine

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