European Journal of Cardiovascular Medicine

Introduction: Acute kidney injury is defined by a quick decline in renal function, and it is frequently linked to the emergence of serious complications as well as an independent mortality risk in patients who have been admitted. Methods: To evaluate the importance of urinary biomarkers tissue inhibitor metalloproteinase and IGFBP 7 (Insulin growth factor binding protein 7) in early detection and diagnosis of acute kidney damage in patients presenting to emergency room. Study site: emergency room and the ICU (medical, cardiac and surgical) at a tertiary health care centre. Study population: All patients attended the emergency room and admitted in medical and surgical units for 18 months were included in the study. It is a prospective, observational double blinded study. Study period:  January 2018 to June 2019. Sample size 120 patients.  Results: In our study population, serum creatinine (<1.1 and 1.1) and nephroncheck values were compared at admission and there was statistical correlation between nephrocheck and creatinine (P=.04565) and serum creatinine and urinary biomarkers values were correlated at 48 Hrs after admission, there was no statistical correlation between urinary biomarkers and creatinine(P=0.3463). Conclusion: Acute kidney injury was two times more common in above 50 years of age. High early mortality in AKI (Acute kidney injury) died within 48 hours of enrollment. Tachycardia and hypotension are associated with ATI (acute tubular injury) as manifested by high levels of biomarkers at 48 hours. Hypoxemia also contributes to acute kidney injury. Patients with initial normal nephrocheck values are unlikely to have serum creatinine>1.1 at 48 hours.