European Journal of Cardiovascular Medicine

NLR and CRP are established markers that reflect systemic inflammatory, and these parameters alter in patients with novel coronavirus (SARS-CoV-2) pneumonia (COVID-19).  AIM: This research aimed to investigate neutrophil-to-lymphocyte ratio (NLR) with C-reactive protein to identify potential clinical predictors and analyze the severity & outcome of patients. Materials & Methods: This study was conducted in a tertiary care centre for covid management at a Govt  medical college , Ernakulam. It is a retrospective study on 972 RTPCR positive , covid patients, admitted from March 1st 2020 to Sept 30^th 2020. Analysis: Quantitative variables were summarized as Mean & Standard deviation. 95% Confidence Interval was estimated Qualitative variables were summarized as frequency & Percentage. Pearson Chi square test was used to find out the association between NLR & CRP with symptomatology, comorbidities, category & severity of the disease, development of complications & outcome. Odds Ratio was calculated. T test was used to find the association between NLR & CRP with length of hospital stay. Results: NLR was >6 in 885(91%) & elevated CRP was observed in 473(48.6%) patients.Our study , proved that high NLR & CRP levels had a negative co-relation with severity of covid disease, as seen with other similar studies. Elevated NLR & CRP promoted COVID 19 progression & development of complications & organ failures. Conclusion: Our study concluded that patients with high NLR & CRP, on admission are more prone to progress into covid pneumonia & respiratory failure. This study showed that NLR & CRP are very useful indicators for predicting the development of complications, causing multiorgan dysfunction.