Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities including central obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low HDL cholesterol, which increase the risk of cardiovascular disease and type 2 diabetes mellitus. Serum ferritin, an indicator of body iron stores and inflammation, has been increasingly associated with insulin resistance and metabolic disturbances. Aims and Objectives: To evaluate serum ferritin levels in patients with metabolic syndrome and determine its association with various components of metabolic syndrome. Materials and Methods: A cross-sectional observational study was conducted in the Department of General Medicine, RIMS Hospital ,RIMS ,Raichur involving 100 patients diagnosed with metabolic syndrome. Clinical history, anthropometric measurements, and laboratory investigations including fasting plasma glucose, HbA1c, lipid profile, renal function tests, complete blood count, and serum ferritin were performed. Statistical analysis was carried out using appropriate correlation tests, and a p-value <0.05 was considered statistically significant. Results: The mean age of the study population was 49.67±11.96 years with male predominance (58%). Mean serum ferritin level was 196.15±97.58 ng/mL. Significant positive correlation was observed between serum ferritin and waist circumference (r=0.456, p<0.001) as well as triglyceride levels (r=0.398, p<0.001). Serum ferritin showed a significant inverse correlation with HDL cholesterol (r=−0.229, p=0.022). No significant association was observed between serum ferritin and diabetes mellitus, hypertension, or number of metabolic syndrome components. Conclusion: Serum ferritin levels are elevated in patients with metabolic syndrome and are significantly associated with central obesity and dyslipidemia. Serum ferritin may serve as a useful biomarker for metabolic risk assessment.
Metabolic syndrome (MetS) is a constellation of metabolic abnormalities comprising abdominal obesity, hypertension, hyperglycemia, elevated triglycerides, and reduced high-density lipoprotein (HDL) cholesterol. These abnormalities collectively increase the risk of cardiovascular disease and type 2 diabetes mellitus. The global prevalence of metabolic syndrome has increased significantly due to sedentary lifestyle, unhealthy dietary habits, and rising obesity rates. Serum ferritin is traditionally considered a marker of total body iron stores. However, recent evidence suggests that ferritin also acts as an acute phase reactant and reflects chronic low-grade inflammation associated with metabolic syndrome. Elevated ferritin levels have been linked to insulin resistance, endothelial dysfunction, oxidative stress, and cardiovascular morbidity. Several epidemiological studies have demonstrated positive associations between serum ferritin levels and individual components of metabolic syndrome such as increased waist circumference, hypertriglyceridemia, impaired glucose metabolism, and low HDL cholesterol. Excess iron accumulation may contribute to oxidative stress and adipose tissue inflammation, thereby aggravating metabolic dysfunction and insulin resistance. Despite growing evidence, the exact relationship between serum ferritin and metabolic syndrome remains incompletely understood. Therefore, evaluation of serum ferritin in patients with metabolic syndrome may help identify individuals at higher cardiometabolic risk and improve disease risk stratification.
AIMS AND OBJECTIVES
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